1/25/2024 0 Comments Iron toxicity antidoteHaddad and Winchester's clinical management of poisoning and drug overdose (Fourth ed.). The US Food and Drug Administration proclaimed a regulation. Goldfrank's toxicologic emergencies (Tenth ed.). BackgroundIron poisoning is a major cause of unintentional poisoning death in young children. Quebec, Canada: Centre antipoison du Quebec.īalmadrid, C., & Bono, M. Antidotes en toxicologie d'urgence (3rd ed.). In severe cases, your doctor may administer one of two antidotes: cyanide antidote kit hydroxocobalamin (Cyanokit) The cyanide antidote kit consists of three medications given together: amyl. Serial ophthalmological and audiological testing should be performed, if symptoms noted and then as necessary.īailey, B., Blais, R., Gaudreault, P., Gosselin, S., & Laliberte, M. (2009). Visual disturbances, hearing loss and audiometric abnormalities have been reported, especially if high doses used. Acute iron toxicity includes effects on the GI tract and the cardiovascular, metabolic, hepatic, and central nervous systems.Infection with yersinia species or mucormycosis may be promoted by deferoxamine. ![]() Decreased serum glucose, sodium, calcium and increased blood coagulability.Rapid IV injection (greater than 15 mg/kg/hour) has produced flushing, urticaria, hypotension and shock.Treatment should be interrupted if signs of toxicity occur. Respiratory distress syndrome has been reported following IV administration of excessive doses.Allergic reactions (dermatological, anaphylaxis).Reddish discolouration of the urine as chelated iron is being excreted.If further expert help is required: call Poison Control, available 24/7 at 1-80 in the US. Pain and induration at the site of injection. It is ineffective in the treatment of heavy metal toxicity (e.g., mercury, lead), cyanide, lithium, acids, bases, and toxic alcohols such as methanol.It is a particular problem in refractory anaemias with hyperplastic bone marrow, especially thalassaemia major, where excessive iron absorption from the gut and inappropriate iron therapy can add to the tissue. ![]() ![]() Prompt treatment in the hospital can be life-saving. Severe tissue iron overload can occur in aplastic and other refractory anaemias, mainly as the result of repeated blood transfusions. Any overdose of iron-containing products should be taken seriously.
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